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Hakim Health Sys Res 2007, 9(4): 7-11 Back to browse issues page
Prevalence of Delta agent super-infection and co-infection among HBsAg-positive patients referring to reference IBTO Lab
Abstract:   (15727 Views)

Introduction: The hepatitis D virus (HDV) is a 36-nm virus, which needs hepatitis B virus for replication. Infection by the Delta agent can occur as a co-infection with hepatitis B, which usually causes acute hepatitis, or as a super- infection of hepatitis B infection. The present study was conducted to estimate the prevalence of super infection or co-infection in HBsAg positive patients.

Methods: Anti-HDV (IgM) and HDV Ag by EIA method were tested in 79 HBsAg-positive sera and the liver function tests including SGOT and SGPT were done. All anti-HDV IgM positive samples were tested for anti-HBc IgM by EIA method. The prevalence of super infection was determined.

Results: Delta Ag was not detected in any of the 79 sera. 7 out of 79 (8.8%) samples were positive for anti-HDV(IgM) but they were all negative for anti-HBc IgM. The liver enzyme function tests were elevated in 5 out of 6 samples.

Conclusion: 7 samples were positive for anti-HDV(IgM) and indicated recent infection with HDV in these patients, but anti-HBc (IgM) was not detected, so these serologic data suggest super-infection with Delta agent in HBV-infected patients. In HBsAg-positive patients with liver enzyme elevation, investigating possible HDV infection is strongly recommended.

  

Hakim Research Journal 2007 9(4): 7- 11.

Keywords: Delta hepatitis, hepatitis B, co-infection, super-infection.
Full-Text [PDF 243 kb]   (2530 Downloads)    
Type of Study: Original | Subject: General
Received: 2008/04/16
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Prevalence of Delta agent super-infection and co-infection among HBsAg-positive patients referring to reference IBTO Lab . Hakim Health Sys Res . 2007; 9 (4) :7-11
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Volume 9, Issue 4 (1-2007) Back to browse issues page
فصلنامه پژوهش حکیم Hakim Research Journal
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